Chemistry and biology of ramoplanin: A lipoglycodepsipeptide with potent antibiotic activity

被引：112

作者：

Walker, S ^{[1
]}

Chen, L

Hu, YN

Rew, Y

Shin, DW

Boger, DL

机构：

[1] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 02期

关键词：

D O I：

10.1021/cr030106n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Today, there is a clear need for new antibiotics to treat drug-resistant bacterial infections. Antibiotics that operate by new mechanisms or belong to new structural classes are attractive because they are less likely to show cross-resistance with existing antibiotics. One such antibiotic is ramoplanin which is currently in Phase III clinical trials for the prevention of vancomycin-resistant enterococcal infections in hospitalized patients. Initial results show that the transglycosilation step of peptidoglycan biosynthesis is the likely target for this molecule.

引用

页码：449 / 475

页数：27

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