Development of a Recombinant Epsilon Toxoid Vaccine against Enterotoxemia and Its Use as a Combination Vaccine with Live Attenuated Sheep Pox Virus against Enterotoxemia and Sheep Pox

被引：42

作者：

Chandran, Dev ^{[1
]}

Naidu, Sureddi Satyam ^{[1
]}

Sugumar, Parthasarathy ^{[1
]}

Rani, Gudavalli Sudha ^{[1
]}

Vijayan, Shahana Pallichera ^{[1
]}

Mathur, Deepika ^{[2
]}

Garg, Lalit C. ^{[2
]}

Srinivasan, Villuppanoor Alwar ^{[1
]}

机构：

[1] Indian Immunol Ltd, Hyderabad 500032, Andhra Pradesh, India

[2] Natl Inst Immunol, Gene Regulat Lab, New Delhi 110067, India

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2010年 / 17卷 / 06期

关键词：

WHOLE-CELL VACCINE; PERFRINGENS TYPE-D; ESCHERICHIA-COLI; TOXIN GENE; EXPRESSION; BACTERIA; CLONING; MICE;

D O I：

10.1128/CVI.00013-10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sheep pox and enterotoxemia are important diseases of sheep, and these diseases cause severe economic losses to sheep farmers. The present study was undertaken to evaluate the potential of formaldehyde-inactivated recombinant epsilon toxin as a vaccine candidate. The potency of the recombinant epsilon toxoid with aluminum hydroxide as an adjuvant in sheep was determined. Vaccinated sheep were protected against enterotoxemia, with potency values of >5 IU being protective. Further, the use of this construct in a combination vaccine against sheep pox resulted in the sheep being protected against both sheep pox and enterotoxemia.

引用

页码：1013 / 1016

页数：4

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