Autophagy Regulators as Potential Cancer Therapeutic agents: A Review

被引：70

作者：

Li, Shan ^{[1
]}

Wang, Lingfei ^{[1
]}

Hu, Yongzhou ^{[1
]}

Sheng, Rong ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2015年 / 15卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Autophagy; Autolysosome; Autophagy inducers; Autophagy inhibitors; Beclin1; Cancer treatment; Drug discovery; HISTONE DEACETYLASE INHIBITOR; ROTTLERIN INDUCES AUTOPHAGY; ACTIVATED PROTEIN-KINASE; STRESS-INDUCED AUTOPHAGY; ROS-MEDIATED AUTOPHAGY; MALIGNANT GLIOMA-CELLS; PROSTATE-CANCER; PI3K/AKT/MTOR PATHWAY; PROTECTIVE AUTOPHAGY; INDUCED APOPTOSIS;

D O I：

10.2174/1568026615666150302105343

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Autophagy is an important basic metabolic mechanism by engulfing and degrading the unnecessary or dysfunctional cellular components within double-membered autolysosomes to maintain cellular homeostasis. Autophagy has sparkled great interest for its complicated functions in different stages of cancer, and is regarded as a potential target for anticancer therapy. As a suppressor pathway, autophagy prevents tumor initiation and as a survival pathway, autophagy contributes to tumor growth and progression by attenuating cellular metabolic stress and resisting therapeutic agents-induced cell death. Many autophagy regulators have been identified as potential cancer therapeutic agents and some cytotoxic anticancer drugs also induce autophagy. Combination regimen of autophagy regulators with other anticancer agent exhibits desirable efficacy and several protocols are underway in clinical trials. This review delineates the possible role of autophagy in anticancer therapy, and discusses reported potent autophagy regulators in cancer treatment.

引用

页码：720 / 744

页数：25

共 227 条

[1]

Autophagy delays apoptotic death in breast cancer cells following DNA damage [J].