Comparison of first and second trimester screening for fetal anomalies

被引:46
作者
D'Ottavio, G [1 ]
Mandruzzato, G [1 ]
Meir, YJ [1 ]
Rustico, MA [1 ]
Fischer-Tamaro, L [1 ]
Conoscenti, G [1 ]
Natale, R [1 ]
机构
[1] Ist Infanzia Burlo Garofolo, Dept Obst Gyn, Trieste, Italy
来源
ULTRASOUND SCREENING FOR FETAL ANOMALIES: IS IT WORTH IT?: SCREENING REVISITED AFTER THE EUROFETUS DATA | 1998年 / 847卷
关键词
D O I
10.1111/j.1749-6632.1998.tb08941.x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Four thousand fifty unselected pregnant women bearing a total of 4,078 fetuses were examined by transvaginal sonography (TVS) at 14 weeks of gestational age and rescreened via transabdominal sonography (TAS) at 21 weeks. Fifty-four of 88 anomalies were correctly identified at first scan whereas 34 were not; of these, 24 were discovered at second trimester rescreening, and the remaining 10 were observed later in pregnancy or after birth. The sensitivity of TVS screening with respect to final outcome was 61.4% (54 of 88 malformations in total) and 69.2% in comparison to TAS screening results (54 malformations detected among 78 recognized within 21 weeks). The association between fetal malformation and chromosomal aberrations was also investigated: in our study population there were 21 aneuploides, 14 of which were recognized because of abnormal findings at the 14 weeks' TVS, 5 at the TAS rescreening, and 2 after birth in neonates free of structural abnormalities.
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收藏
页码:200 / 209
页数:10
相关论文
共 14 条
[1]   SCREENING FOR FETAL ANOMALIES DURING THE 1ST TRIMESTER OF PREGNANCY - TRANSVAGINAL VERSUS TRANSABDOMINAL SONOGRAPHY [J].
ACHIRON, R ;
TADMOR, O .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 1991, 1 (03) :186-191
[2]   Anatomical and echocardiographic correlates of normal cardiac morphology in the late first trimester fetus [J].
Allan, LD ;
Santos, R ;
Pexieder, T .
HEART, 1997, 77 (01) :68-72
[3]  
BONILLAMUSOLES FM, 1994, J ULTRAS MED, V13, P347
[4]  
BRONSHTEIN M, 1994, OBSTET GYNECOL, V84, P73
[5]   CONGENITAL-ANOMALIES - MORTALITY AND MORBIDITY, BURDEN AND CLASSIFICATION [J].
CHUNG, CS ;
MYRIANTHOPOULOS, NC .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1987, 27 (03) :505-523
[6]   TRANSVAGINAL ULTRASONOGRAPHIC DETECTION OF CONGENITAL-ANOMALIES IN THE 1ST TRIMESTER [J].
CULLEN, MT ;
GREEN, J ;
WHETHAM, J ;
SALAFIA, C ;
GABRIELLI, S ;
HOBBINS, JC .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (02) :466-476
[7]   EARLY PRENATAL ULTRASONOGRAPHIC DIAGNOSIS OF OSTEOGENESIS IMPERFECTA - A CASE-REPORT [J].
DOTTAVIO, G ;
TAMARO, LF ;
MANDRUZZATO, G .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (02) :384-385
[8]  
DOTTAVIO G, 1995, J ULTRAS MED, V14, P575
[9]  
HANNIGAN VL, 1991, PREVENTION SCREENING, P3
[10]   THE ROLE OF TRANSVAGINAL SONOGRAPHY IN THE EARLY DETECTION OF CONGENITAL HEART-DISEASE [J].
JOHNSON, P ;
SHARLAND, G ;
MAXWELL, D ;
ALLAN, L .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 1992, 2 (04) :248-251