How sphingolipids bind and shape proteins: molecular basis of lipid-protein interactions in lipid shells, rafts and related biomembrane domains

被引：78

作者：

Fantini, J ^{[1
]}

机构：

[1] Fac Sci & Tech St Jerome, Inst Mediterraneen Rech Nutr, Lab Biochim & Physicochim Membranes Biol, UMR INRA 1111, F-13331 Marseille 20, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2003年 / 60卷 / 06期

关键词：

plasma membrane; microdomain; infection; AIDS; Alzheimer; prion; chaperone; HIV-1; virus fusion; lipid rafts; caveolae;

D O I：

10.1007/s00018-003-3003-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding the molecular mechanisms controlling the association of proteins with lipid rafts is a central issue in cell biology and medicine. A structurally conserved motif (the 'sphingolipid binding domain') has been characterized in unrelated cellular and microbial proteins targeted to lipid rafts. I propose that the structuration of a sphingolipid shell around the sphingolipid binding domain not only extracts the protein from the liquid-disordered phase of the plasma membrane, and ensures its delivery to lipid rafts, but also influences its conformation. The chaperone activity of sphingolipids in shells and rafts may play an important role in infectious and conformational diseases (human immunodeficiency virus-1, prions, Alzheimer).

引用

页码：1027 / 1032

页数：6

共 53 条

[1] Cell biology - A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains [J].

Anderson, RGW ;

Jacobson, K .

SCIENCE, 2002, 296 (5574) :1821-1825

[2] Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes [J].

Baron, GS ;

Wehrly, K ;

Dorward, DW ;

Chesebro, B ;

Caughey, B .

EMBO JOURNAL, 2002, 21 (05) :1031-1040

[3] Lipid-assisted protein folding [J].

Bogdanov, M ;

Dowhan, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (52) :36827-36830

[4] Structure and function of sphingolipid- and cholesterol-rich membrane rafts [J].

Brown, DA ;

London, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17221-17224

[5] Functions of lipid rafts in biological membranes [J].

Brown, DA ;

London, E .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 :111-136

[6] SORTING OF GPI-ANCHORED PROTEINS TO GLYCOLIPID-ENRICHED MEMBRANE SUBDOMAINS DURING TRANSPORT TO THE APICAL CELL-SURFACE [J].

BROWN, DA ;

ROSE, JK .

CELL, 1992, 68 (03) :533-544

[7]

Brown RE, 1998, J CELL SCI, V111, P1

[8] BINDING OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I (HIV-1) GP120 TO GALACTOSYLCERAMIDE (GALCER) - RELATIONSHIP TO THE V3 LOOP [J].

COOK, DG ;

FANTINI, J ;

SPITALNIK, SL ;

GONZALEZSCARANO, F .

VIROLOGY, 1994, 201 (02) :206-214

[9] TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts [J].

Drevot, P ;

Langlet, C ;

Guo, XJ ;

Bernard, AM ;

Colard, O ;

Chauvin, JP ;

Lasserre, R ;

He, HT .

EMBO JOURNAL, 2002, 21 (08) :1899-1908

[10] The state of lipid rafts: From model membranes to cells [J].

Edidin, M .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2003, 32 :257-283

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