Imprinted genes in the placenta - A review

被引：173

作者：

Coan, PM ^{[1
]}

Burton, GJ ^{[1
]}

Ferguson-Smith, AC ^{[1
]}

机构：

[1] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England

来源：

PLACENTA | 2005年 / 26卷

关键词：

imprinted genes; placenta; development;

D O I：

10.1016/j.placenta.2004.12.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Imprinted genes are expressed monoallelically depending on their parental origin. High expression of the majority of imprinted genes tested to date has been demonstrated in extraembryonic tissues; placenta and yolk sac. Several mouse models where specific imprinted genes have been disrupted demonstrate that fetal and placental growth may be regulated by imprinted genes, in which paternally expressed genes enhance, and maternally expressed genes restrain, growth. We review the current information on, and suggest possible functional roles for, imprinted genes in placental development. © 2005 Published by IFPA and Elsevier Ltd.

引用

页码：S10 / S20

页数：11

共 87 条

[1] Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation [J].