Cardiac nitric oxide: Emerging role for nNOS in regulating physiological function

被引：62

作者：

Danson, EJ

Choate, JK

Paterson, DJ

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

[2] Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia

来源：

PHARMACOLOGY & THERAPEUTICS | 2005年 / 106卷 / 01期

关键词：

neuronal NO-synthase; contraction; catecholamines; autonomic nervous system;

D O I：

10.1016/j.pharmthera.2004.11.003

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Emerging evidence shows that neuronal nitric oxide synthase (nNOS) plays several diverging roles in modulating cardiac function. This review examines the nitric oxide (NO) pathway and the regulatory mechanisms to which nNOS signalling is sensitive. These mechanisms are diverse and include regulation of gene expression, posttranscriptional regulation, protein trafficking, allosteric modulation of nNOS and redox modification to alter NO bioavailability once synthesised. Functionally, alteration in nNOS-NO signalling in the heart may correlate with different cardiac regulatory states. The idea of this being associated with exercise-trained states and myocardial disease is discussed. (c) 2004 Elsevier Inc. All rights reserved.

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收藏

页码：57 / 74

页数：18

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