Solid-phase glycopeptide synthesis of tyrosine-glycosylated glycogenin fragments as substrates for glucosylation by glycogenin

被引：26

作者：

Jansson, AM

Jensen, KJ

Meldal, M

Lomako, J

Lomako, WM

Olsen, CE

Bock, K

机构：

[1] CARLSBERG LAB,DEPT CHEM,DK-2500 VALBY,COPENHAGEN,DENMARK

[2] UNIV MIAMI,SCH MED,DEPT BIOCHEM & MOLEC BIOL,MIAMI,FL 33101

[3] ROYAL VET & AGR UNIV,DEPT CHEM,DK-1871 FREDERIKSBERG C,DENMARK

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 10期

关键词：

D O I：

10.1039/p19960001001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The four building blocks N-alpha-Fmoc-Tyr(Bz(4)-alpha-D-Glc)-OPfp 1, N-alpha-Fmoc-Tyr(Bz(4)-beta-D-Glc)-OPfp 2, N-alpha-Fmoc-Tyr [Bz(4)-alpha-D-Glc-(1-->4)-Bz(3)-alpha-D-Glc]-OPfp 3 and N-alpha-Fmoc-Tyr[Ac-4-alpha-D-Glc-(1-->4)-Ac-3-beta-D-Glc]-OPfp 4 were used in continuous-how solid-phase synthesis of four 25-amino-acid-long glycopeptides 5-8 related to glycogenin, The unglycosylated peptide 9 was synthesized as well, and the five glycogenin fragments were tested as accepters for glucosyl transfer by recombinant glycogenin.

引用

页码：1001 / 1006

页数：6

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