Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components

被引：34

作者：

Tarailo, Maja ^{[1
]}

Tarailo, Sanja ^{[1
]}

Rose, Ann M. ^{[1
]}

机构：

[1] Univ British Columbia, Fac Med, Dept Med Genet, Vancouver, BC V6T 1Z3, Canada

来源：

GENETICS | 2007年 / 177卷 / 04期

关键词：

D O I：

10.1534/genetics.107.080408

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Here, we report genetic interactions with mdf-1 (gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic "interlogs" and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CEMP-F-related proteins,recently implicated in the spindle assembly check-point (SAC) function, do not have identical functions, since hcp-1 (RNAi), but not hcp-2 (RNAi), enhances the lethality of the SAC mutants.

引用

页码：2525 / 2530

页数：6

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