Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study

被引：15

作者：

Andersen, Vibeke ^{[1
]}

Christensen, Jane ^{[2
]}

Overvad, Kim ^{[4
,5
]}

Tjonneland, Anne ^{[2
]}

Vogel, Ulla ^{[3
,6
]}

机构：

[1] Viborg Reg Hosp, Dept Med, DK-8800 Viborg, Denmark

[2] Inst Canc Epidemiol, Danish Canc Soc, Copenhagen, Denmark

[3] Natl Res Ctr Working Environm, Copenhagen, Denmark

[4] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[5] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[6] Tech Univ Denmark, Natl Food Inst, Soborg, Denmark

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2011年 / 23卷 / 03期

关键词：

carcinogenesis; cohort; epidemiology; gene-environment interaction; population-based; prospective study; red and processed meat; PROSPECTIVE COHORT; HEART-DISEASE; RED MEAT; PROMOTER; ALCOHOL; GENE;

D O I：

10.1097/MEG.0b013e3283417f76

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis. Methods Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated. Results No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates = 0.29). No interaction with meat intake was found (P value for interaction = 0.55). Conclusion The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development. Eur J Gastroenterol Hepatol 23: 282-285 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

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页码：282 / 285

页数：4

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