Unbreakable Codes in Electrospun Fibers: Digitally Encoded Polymers to Stop Medicine Counterfeiting

被引：63

作者：

Huang, Chaobo ^{[1
]}

Lucas, Bart ^{[1
]}

Vervaet, Chris ^{[2
]}

Braeckmans, Kevin ^{[1
]}

Van Calenbergh, Serge ^{[3
]}

Karalic, Izet ^{[3
]}

Vandewoestyne, Mado ^{[4
]}

Deforce, Dieter ^{[4
]}

Demeester, Jo ^{[1
]}

De Smedt, Stefaan C. ^{[1
]}

机构：

[1] Univ Ghent, Dept Pharmaceut, Lab Gen Biochem & Phys Pharm, Ghent Res Grp Nanomed, Ghent, Belgium

[2] Univ Ghent, Dept Pharmaceut, Pharmaceut Technol Lab, Ghent, Belgium

[3] Univ Ghent, Dept Pharmaceut, Med Chem Lab, Ghent, Belgium

[4] Univ Ghent, Dept Pharmaceut, Lab Pharmaceut Biotechnol, Ghent, Belgium

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 24期

关键词：

DIFFUSION MEASUREMENTS; MICROCARRIERS; TABLETS; DRUGS;

D O I：

10.1002/adma.201000130

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluorescent polymer solutions can easily be electrospun into micrometer-sized fibers and subsequently encoded with long lasting digital codes by a photobleaching process. Such encoded fibers may find various applications; as illustrated in this report, placing encoded fibers in drug tablets may become a strategy to protect them from counterfeiting.

引用

页码：2657 / +

页数：7

共 31 条

[1]

Aldhous P, 2005, NATURE, V434, P132, DOI 10.1038/434132a

[2]

[Anonymous], HDB PHARM EXCIPIENTS

[3] FDA moves to curb drug counterfeiting [J].

Ault, A .

LANCET, 2003, 362 (9380) :301-301

[4] Composition profiling of seized ecstasy tablets by Raman spectroscopy [J].

Bell, SEJ ;

Burns, DT ;

Dennis, AC ;

Matchett, LJ ;

Speers, JS .

ANALYST, 2000, 125 (10) :1811-1815

[5] Encoding microcarriers by spatial selective photobleaching [J].

Braeckmans, K ;

De Smedt, SC ;

Roelant, C ;

Leblans, M ;

Pauwels, R ;

Demeester, J .

NATURE MATERIALS, 2003, 2 (03) :169-173

[6] Encoding microcarriers: Present and future technologies [J].

Braeckmans, K ;

De Smedt, SC ;

Leblans, M ;

Pauwels, R ;

Demeester, J .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (06) :447-456

[7] Line FRAP with the confocal laser scanning microscope for diffusion measurements in small regions of 3-D samples [J].

Braeckmans, Kevin ;

Remaut, Katrien ;

Vandenbroucke, Roosmarijn E. ;

Lucas, Bart ;

De Smedt, Stefaan C. ;

Demeester, Joseph .

BIOPHYSICAL JOURNAL, 2007, 92 (06) :2172-2183

[8]

Burns W, 2006, B WORLD HEALTH ORGAN, V84, P689

[9] Electrospun collagen-chitosan nanofiber: A biomimetic extracellular matrix for endothelial cell and smooth muscle cell [J].

Chen, Z. G. ;

Wang, P. W. ;

Wei, B. ;

Mo, X. M. ;

Cui, F. Z. .

ACTA BIOMATERIALIA, 2010, 6 (02) :372-382

[10] The global threat of counterfeit drugs: Why industry and governments must communicate the dangers [J].

Cockburn, R ;

Newton, PN ;

Agyarko, EK ;

Akunyili, D ;

White, NJ .

PLOS MEDICINE, 2005, 2 (04) :302-308

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