Synthesis of [1,2,4]triazolo[4,3-α,]piperazines via highly reactive chloromethyloxadiazoles

被引：38

作者：

Balsells, J ^{[1
]}

DiMichele, L ^{[1
]}

Liu, JC ^{[1
]}

Kubryk, M ^{[1
]}

Hansen, K ^{[1
]}

Armstrong, JD ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 06期

关键词：

D O I：

10.1021/ol0474406

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise, modular approach for the synthesis of [1,2,4]triazolo[4,3-alpha]piperazines via condensation of highly reactive chloromethyloxadiazoles with ethylenediamines is described. NMR studies of this reaction provide evidence that suggests a novel activation mechanism for electrondeficient chloromethyloxadiazoles.

引用

收藏

页码：1039 / 1042

页数：4

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