BST-2 Diminishes HIV-1 Infectivity

被引：28

作者：

Zhang, Jianyong ^{[1
,2
]}

Liang, Chen ^{[1
,2
,3
]}

机构：

[1] Jewish Gen Hosp, McGill AIDS Ctr, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Med, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 23期

基金：

加拿大健康研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; DOWN-MODULATION; CELL-SURFACE; VPU; PROTEIN; RESTRICTION; RELEASE; BST-2/TETHERIN; DEGRADATION; DOMAIN;

D O I：

10.1128/JVI.01228-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bone marrow stromal cell antigen 2 (BST-2, also known as tetherin/CD317/HM1.24) inhibits the release of human immunodeficiency virus type 1 (HIV-1) and other enveloped viruses by tethering virus particles to the cell surface. In this study, we provide evidence not only that the yield of cell-free HIV-1 particles is significantly reduced by BST-2 but also that the infectivity of these progeny virions is severely impaired. The lowered virion infectivity is due to the accumulation of pr55 Gag precursor and the p40Gag intermediates as well as to the loss of a mature core in the majority of HIV-1 particles. These data suggest that, in addition to impeding the release of HIV-1 particles from host cells, BST-2 may also interfere with the activation of viral protease and, as a result, impairs viral Gag processing as well as maturation of HIV-1 particles.

引用

页码：12336 / 12343

页数：8

共 40 条

[1] Tetherin Restricts Productive HIV-1 Cell-to-Cell Transmission [J].

Casartelli, Nicoletta ;

Sourisseau, Marion ;

Feldmann, Jerome ;

Guivel-Benhassine, Florence ;

Mallet, Adeline ;

Marcelin, Anne-Genevieve ;

Guatelli, John ;

Schwartz, Olivier .

PLOS PATHOGENS, 2010, 6 (06)

[2] Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism [J].

Douglas, Janet L. ;

Viswanathan, Kasinath ;

McCarroll, Matthew N. ;

Gustin, Jean K. ;

Frueh, Klaus ;

Moses, Ashlee V. .

JOURNAL OF VIROLOGY, 2009, 83 (16) :7931-7947

[3] Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment [J].

Dube, Mathieu ;

Roy, Bibhuti Bhusan ;

Guiot-Guillain, Pierre ;

Binette, Julie ;

Mercier, Johanne ;

Chiasson, Antoine ;

Cohen, Eric A. .

PLOS PATHOGENS, 2010, 6 (04) :1-19

[4] Direct Restriction of Virus Release and Incorporation of the Interferon-Induced Protein BST-2 into HIV-1 Particles [J].

Fitzpatrick, Kathleen ;

Skasko, Mark ;

Deerinck, Thomas J. ;

Crum, John ;

Ellisman, Mark H. ;

Guatelli, John .

PLOS PATHOGENS, 2010, 6 (03)

[5] HIV-1 Gag proteins: Diverse functions in the virus life cycle [J].

Freed, EO .

VIROLOGY, 1998, 251 (01) :1-15

[6] HIV-1 Antagonism of CD317 Is Species Specific and Involves Vpu-Mediated Proteasomal Degradation of the Restriction Factor [J].

Goffinet, Christine ;

Allespach, Ina ;

Homann, Stefanie ;

Tervo, Hanna-Mari ;

Habermann, Anja ;

Rupp, Daniel ;

Oberbremer, Lena ;

Kern, Christian ;

Tibroni, Nadine ;

Welsch, Sonja ;

Krijnse-Locker, Jacomine ;

Banting, George ;

Kraeusslich, Hans-Georg ;

Fackler, Oliver T. ;

Keppler, Oliver T. .

CELL HOST & MICROBE, 2009, 5 (03) :285-297

[7] EFFECT OF MUTATIONS AFFECTING THE P6 GAG PROTEIN ON HUMAN-IMMUNODEFICIENCY-VIRUS PARTICLE RELEASE [J].

GOTTLINGER, HG ;

DORFMAN, T ;

SODROSKI, JG ;

HASELTINE, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3195-3199

[8] Mutation of a Single Residue Renders Human Tetherin Resistant to HIV-1 Vpu-Mediated Depletion [J].

Gupta, Ravindra K. ;

Hue, Stephane ;

Schaller, Torsten ;

Verschoor, Ernst ;

Pillay, Deenan ;

Towers, Greg J. .

PLOS PATHOGENS, 2009, 5 (05)

[9] CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus Infection [J].

Habermann, Anja ;

Krijnse-Locker, Jacomine ;

Oberwinkler, Heike ;

Eckhardt, Manon ;

Homann, Stefanie ;

Andrew, Amy ;

Strebel, Klaus ;

Kraeusslich, Hans-Georg .

JOURNAL OF VIROLOGY, 2010, 84 (09) :4646-4658

[10] Structural Basis of HIV-1 Tethering to Membranes by the BST-2/Tetherin Ectodomain [J].

Hinz, Andreas ;

Miguet, Nolwenn ;

Natrajan, Ganesh ;

Usami, Yoshiko ;

Yamanaka, Hikaru ;

Renesto, Patricia ;

Hartlieb, Bettina ;

McCarthy, Andrew A. ;

Simorre, Jean-Pierre ;

Goetlinger, Heinrich ;

Weissenhorn, Winfried .

CELL HOST & MICROBE, 2010, 7 (04) :314-323

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