MicroRNA biogenesis: Drosha can't cut it without a partner

被引：113

作者：

Tomari, Y ^{[1
]}

Zamore, PD ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

来源：

CURRENT BIOLOGY | 2005年 / 15卷 / 02期

关键词：

D O I：

10.1016/j.cub.2004.12.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ribonuclease Drosha requires a dedicated double-stranded RNA binding protein to convert long, nuclear primary microRNA transcripts into shorter pre-microRNA stem-loops, the cytoplasmic precursors from which mature microRNAs are ultimately excised.

引用

页码：R61 / R64

页数：4

共 20 条

[1] Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs [J].

Bohnsack, MT ;

Czaplinski, K ;

Görlich, D .

RNA, 2004, 10 (02) :185-191

[2] Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].

Cai, XZ ;

Hagedorn, CH ;

Cullen, BR .

RNA, 2004, 10 (12) :1957-1966

[3] Processing of primary microRNAs by the Microprocessor complex [J].

Denli, AM ;

Tops, BBJ ;

Plasterk, RHA ;

Ketting, RF ;

Hannon, GJ .

NATURE, 2004, 432 (7014) :231-235

[4] The Microprocessor complex mediates the genesis of microRNAs [J].

Gregory, RI ;

Yan, KP ;

Amuthan, G ;

Chendrimada, T ;

Doratotaj, B ;

Cooch, N ;

Shiekhattar, R .

NATURE, 2004, 432 (7014) :235-240

[5]

HAN J, 2005, IN PRESS GENES DEV

[6] The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation [J].

Han, MH ;

Goud, S ;

Song, L ;

Fedoroff, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (04) :1093-1098

[7] Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions [J].

Kurihara, Y ;

Watanabe, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (34) :12753-12758

[8] The human DiGeorge syndrome critical region gene 8 and its D-melanogaster homolog are required for miRNA biogenesis [J].

Landthaler, M ;

Yalcin, A ;

Tuschl, T .

CURRENT BIOLOGY, 2004, 14 (23) :2162-2167

[9] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].

LEE, RC ;

FEINBAUM, RL ;

AMBROS, V .

CELL, 1993, 75 (05) :843-854

[10] The nuclear RNase III Drosha initiates microRNA processing [J].

Lee, Y ;

Ahn, C ;

Han, JJ ;

Choi, H ;

Kim, J ;

Yim, J ;

Lee, J ;

Provost, P ;

Rådmark, O ;

Kim, S ;

Kim, VN .

NATURE, 2003, 425 (6956) :415-419

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