Triterpenes and lignans from Artemisia caruifolia and their cytotoxic effects on Meth-A and LLC tumor cell lines

被引：29

作者：

Ma, CM ^{[1
]}

Nakamura, N ^{[1
]}

Min, BS ^{[1
]}

Hattori, M ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 02期

关键词：

Artemisia caruifolia; caruilignan; cytotoxicity; lignan; 3; beta-hydroxy-29-norcycloart-24-one;

D O I：

10.1248/cpb.49.183

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One new triterpene, 3 beta -hydroxy-29-norcycloart-24-one (1), and four new lignans, caruilignans (2-5), together with six known compounds were isolated from the aerial part of Artemisia caruifolia BUCH.-HAM. ex TOXB. Their structures were determined by various spectroscopic means. Most of the isolated lignans were moderately cytotoxic to Meth-A cells with ED50 values of 5-10 mug/ml, but not to Lowis lung carcinoma (LLC) cells. An oxime derivative of 1 showed more potent cytotoxic activity against Meth-A and LLC cells than the original triterpene 1.

引用

页码：183 / 187

页数：5

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