Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms

被引：34

作者：

Gull, K ^{[1
]}

Alsford, S ^{[1
]}

Ersfeld, K ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0966-842X(98)01314-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In addition to 11 pairs of housekeeping chromosomes, the genome of Trypanosoma brucei contains similar to 100 minichromosomes that are probably involved in the ability of the parasite to evade the host's immune response. This minichromosomal population is segregated on the mitotic spindle. How this is achieved provides insight into potential segregation mechanisms for small DNA molecules in eukaryotic microorganisms.

引用

页码：319 / 323

页数：5

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