No heroin or morphine 6β-glucuronide analgesia in μ-opioid receptor knockout mice

被引：45

作者：

Kitanaka, N

Sora, I

Kinsey, S

Zeng, ZZ

Uhl, GR

机构：

[1] NIDA, Mol Neurobiol Branch, Intramural Res Program, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 355卷 / 01期

关键词：

morphine; pain; opiate;

D O I：

10.1016/S0014-2999(98)00516-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent reports suggest that heroin and its metabolite morphine 6 beta-glucuronide can produce analgesia independent of the morphine-preferring mu-opioid receptor. We have tested heroin and morphine 6 beta-glucuronide analgesia in wild-type, homozygous and heterozygous mu-opioid receptor knockout mice. Homozygotes display no heroin or morphine 6 beta-glucuronide analgesia. Heterozygous mice with one mu-opioid receptor gene copy reveal reduced heroin and morphine 6 beta-glucuronide analgesia. The mu-opioid receptor-dependence of heroin and morphine 6 beta-glucuronide fails to support a requirement for a heroin-specific opiate receptor subtype. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：R1 / R3

页数：3

共 7 条

[1] MORPHINE-6-GLUCURONIDE - ANALGESIC EFFECTS AND RECEPTOR-BINDING PROFILE IN RATS [J].