Non-Hodgkin lymphomas of mice

被引：10

作者：

Hori, M

Xiang, S

Qi, CF

Chattopadhyay, SK

Fredrickson, TN

Hartley, JW

Kovalchuk, AL

Bornkamm, GW

Janz, S

Copeland, NG

Jenkins, NA

Ward, JM

Morse, HC

机构：

[1] NIAID, LIP, NIH, Bethesda, MD 20892 USA

[2] NIAID, Immunopathol Lab, NIH, Bethesda, MD 20892 USA

[3] NIAID, Genet Lab, Off Lab Anim Sci, NIH, Bethesda, MD 20892 USA

[4] GSF Forschungszentrum Umwelt & Gesundheit, Inst Klin Mol Biol & Tummorgenet, Munich, Germany

[5] NCI, Mouse Canc Genet Program, Off Lab Anim Sci, NIH, Bethesda, MD 20892 USA

[6] NCI, Vet & Tumor Pathol Sect, Off Lab Anim Sci, NIH, Bethesda, MD 20892 USA

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2001年 / 27卷 / 01期

关键词：

BCL6; Burkitt lymphoma; mouse lymphoma; MYC; non-Hodgkin lymphoma;

D O I：

10.1006/bcmd.2000.0375

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies of lymphoid neoplasms occurring in normal or genetically engineered mice have revealed parallels and differences to non-Hodgkin lymphomas (NHL) of humans. Some mouse lymphomas have strong histologic similarities to the human NHL subsets including precursor B- and T-cell lymphoblastic, small lymphocytic, splenic marginal zone, and diffuse large-cell B-cell lymphomas (DLCL); whether molecular parallels also exist is under study. Others mouse types such as sIg(+) lymphoblastic B-cell lymphoma have no histologic equivalent in human NHL even though they share molecular deregulation of BCL6 with human DLCL. Finally, Burkitt lymphoma does not appear to occur naturally in mice, but it can be induced with appropriately engineered transgenes.

引用

页码：217 / 222

页数：6

共 26 条

[1] THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE [J].