Transcriptome analysis of NF-κB- and phosphatidylinositol 3-kinase-regulated genes in human cytomegalovirus-infected monocytes

被引:46
作者
Chan, Gary [1 ]
Bivins-Smith, Elizabeth R. [1 ]
Smith, M. Shane [1 ]
Yurochko, Andrew D. [1 ,2 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, Ctr Mol & Tumor Virol, Shreveport, LA 71130 USA
[2] Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA USA
关键词
D O I
10.1128/JVI.00864-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human cytomegalovirus induces a proinflammatory monocyte following infection, and we have evidence that NF-kappa B and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signaling pathways are responsible for the rapid activation of infected monocytes, we examined the role that these pathways played in the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed that a significant number of genes, including inflammatory genes, were regulated in an NF-kappa B- and/or PI(3)K-dependent manner, identifying the NF-kappa B and PI(3)K pathways as key cellular control points in the conversion of monocytes to an activated proinflammatory state following HCMV infection.
引用
收藏
页码:1040 / 1046
页数:7
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