Haplotype-based genetics in mice and rats

被引：23

作者：

Cuppen, E ^{[1
]}

机构：

[1] Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 06期

关键词：

D O I：

10.1016/j.tig.2005.03.010

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.

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页码：318 / 322

页数：5

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