Paget's disease of bone

被引：60

作者：

Appelman-Dijkstra, Natasha M. ^{[1
]}

Papapoulos, Socrates E. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Ctr Bone Qual, Med, Leiden, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2018年 / 32卷 / 05期

关键词：

bone turnover; genetics; Paget's disease; SQSTM1; zoledronate; VIRUS NUCLEOCAPSID PROTEIN; GENOME-WIDE ASSOCIATION; SYMPTOMATIC MANAGEMENT; FAMILIAL AGGREGATION; RANDOMIZED-TRIAL; ZOLEDRONIC ACID; SINGLE INFUSION; GENETIC RISK; SUSCEPTIBILITY; MUTATIONS;

D O I：

10.1016/j.beem.2018.05.005

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：657 / 668

页数：12

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