Efficient and practical synthesis of the A-ring precursor of 19-nor-1α,25-dihydroxyvitamin D3 and its 13C, or 2H-labeled derivative

被引：18

作者：

Hanazawa, T ^{[1
]}

Inamori, H ^{[1
]}

Masuda, T ^{[1
]}

Okamoto, S ^{[1
]}

Sato, F ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 14期

关键词：

D O I：

10.1021/ol016052q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The A-ring precursor of 19-nor-1 alpha ,25-dihydroxyvitamin D-3 (1) and its C-13- or H-2-labeled derivative were efficiently synthesized from readily available, optically active 5-(tert-butyldimethylsilyloxy)-2-cyclohexenone (2) through a five step reaction in 68% overall yield.

引用

页码：2205 / 2207

页数：3

共 23 条

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