High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study

被引：72

作者：

Kavsak, Peter A. ^{[2
]}

Walsh, Mike ^{[2
]}

Srinathan, Sadeesh ^{[3
]}

Thorlacius, Laurel ^{[3
]}

Buse, Giovanna Lurati ^{[1
]}

Botto, Fernando ^{[1
]}

Pettit, Shirley ^{[4
]}

McQueen, Matthew J. ^{[2
]}

Hill, Stephen A. ^{[2
]}

Thomas, Sabu ^{[2
]}

Mrkobrada, Marko ^{[2
]}

Alonso-Coello, Pablo ^{[5
]}

Berwanger, Otavio ^{[6
]}

Biccard, Bruce M. ^{[7
]}

Cembrowski, George ^{[8
]}

Chan, Matthew T. V. ^{[9
]}

Chow, Clara K. ^{[10
]}

de Miguel, Angeles ^{[11
]}

Garcia, Mercedes ^{[11
]}

Graham, Michelle M. ^{[8
]}

Jacka, Michael J. ^{[8
]}

Kueh, J. H. ^{[12
]}

Li, Stephen C. H. ^{[13
]}

Lit, Lydia C. W. ^{[9
]}

Martinez-Bru, Cecilia ^{[14
]}

Naidoo, Prebashini ^{[7
]}

Nagele, Peter ^{[15
]}

Pearse, Rupert M. ^{[16
]}

Rodseth, Reitze N. ^{[7
]}

Sessler, Daniel I. ^{[17
]}

Sigamani, Alben ^{[18
,19
]}

Szczeklik, Wojciech ^{[20
]}

Tiboni, Maria ^{[2
]}

Villar, Juan Carlos ^{[21
,22
]}

Wang, C. Y. ^{[12
]}

Xavier, Denis ^{[18
,19
]}

Devereaux, P. J. ^{[1
]}

机构：

[1] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON L8L 2X2, Canada

[2] McMaster Univ, Hamilton, ON L8N 3Z5, Canada

[3] Univ Manitoba, Hlth Sci Ctr, Winnipeg, MB R3A 1R9, Canada

[4] Hamilton Hlth Sci Ctr, Hamilton, ON L8L 2X2, Canada

[5] Hosp Santa Creu & Sant Pau, Iberoamerican Cochrane Ctr, Barcelona 08041, Spain

[6] Hosp Coracao, BR-04005000 Sao Paulo, Brazil

[7] Inkosi Albert Luthuli Cent Hosp, Nelson R Mandela Sch Med, ZA-4013 Congella, Kwazulu Natal, South Africa

[8] Univ Alberta Hosp, Edmonton, AB T6G 2B7, Canada

[9] Chinese Univ Hong Kong, Prince Wales Hosp, Satin, Hong Kong, Peoples R China

[10] George Inst Global Hlth, Camperdown, NSW 2050, Australia

[11] Hosp Gregorio Maranon, Madrid 28007, Spain

[12] Univ Malaya, Kuala Lumpur 50603, Malaysia

[13] Westmead Hosp, Inst Clin Pathol & Med Res, Sydney W Area Hlth Serv, Wentworthville, NSW 2145, Australia

[14] Hosp Santa Creu & Sant Pau, Barcelona 08025, Spain

[15] Washington Univ, Sch Med, St Louis, MO 63110 USA

[16] Barts & London Queen Marys Sch Med & Dent, London E1 2AT, England

[17] Cleveland Clin, Cleveland, OH 44195 USA

[18] St Johns Med Coll, Bangalore 560034, Karnataka, India

[19] St Johns Res Inst, Bangalore 560034, Karnataka, India

[20] Jagiellonian Univ, Coll Med, PL-31008 Krakow, Poland

[21] Univ Autonoma Bucaramanga, Bogota, Colombia

[22] Fdn Cardioinfantilinst Cardiol, Bogota, Colombia

来源：

CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 12期

基金：

加拿大健康研究院;

关键词：

High sensitivity troponin T; 99th percentile; Reference interval; Concentration change; Noncardiac surgery; CARDIAC TROPONIN; MYOCARDIAL-INFARCTION; ASSAY; POPULATION; PREDICTION; VALIDATION; DISEASE;

D O I：

10.1016/j.clinbiochem.2011.05.017

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. Design and methods: We measured hs-TnT preoperatively and postoperatively on days 1,2 and 3 in 325 adults. Results: Postoperatively 45% (95% CI: 39-50%) of patients had hs-TnT >= 14 ng/L and 22% (95% CI: 17-26%) had an elevation (>= 14 ng/L) and change (>85%) in hs-TnT. Conclusion: Further research is needed to inform the optimal hs-TnT threshold and change in this setting. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1021 / 1024

页数：4

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