Psychiatric comorbidity in adult patients with idiopathic generalized epilepsy

被引：32

作者：

Akanuma, Nozomi ^{[1
,2
,3
]}

Hara, Eriko ^{[2
,4
]}

Adachi, Naoto ^{[5
]}

Haraf, Koichiro ^{[6
]}

Koutroumanidis, Michael ^{[2
]}

机构：

[1] S London & Maudsley NHS Fdn Trust, Lambeth Rehabil Serv, London SW9 6AA, England

[2] Guys & St Thomas NHS Fdn Trust, Dept Clin Neurophysiol & Epilepsies, London, England

[3] Kings Coll London, Inst Psychiat, Dept Clin Neurosci, London WC2R 2LS, England

[4] Tokyo Med & Dent Univ, Grad Sch, Tokyo, Japan

[5] Adachi Med Clin, Sapporo, Hokkaido, Japan

[6] UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London, England

来源：

EPILEPSY & BEHAVIOR | 2008年 / 13卷 / 01期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

epilepsy; idiopathic generalized epilepsy; psychiatric disorders; comorbidity; neuropsychiatry;

D O I：

10.1016/j.yebeh.2008.01.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];

摘要：

We reviewed the medical records of 157 adult (>= 18 years) patients with firmly diagnosed idiopathic generalized epilepsy (IGE) to investigate the extent and the type of psychiatric comorbidity and its relationship to various IGE syndromes and other epilepsy-related neurobioloaical factors. Forty-one patients (26.1%, 14 men and 27 women, median age: 34.0 years, range: 18-68, mean: 36.5) had comorbid mental disorders according to the 10th revision of the International Classification of Diseases (ICD-10) criteria, with four patients having a dual diagnosis. Mood disorders were the most common comorbid mental disorder (46.7%), followed by anxiety-panic disorder (26.7%). Cornorbid psychiatric disorders occurred in all syndromes and in association with all seizure types, and, as in focal epilepsies, seizure control was significantly better in patients without psychiatric comorbidity (40.5% vs 19.5%, chi(2)(1) = 5.873, P = 0.015). (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：248 / 251

页数：4

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