Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

被引：1925

作者：

Galluzzi, L. ^{[1
,2
]}

Vitale, I. ^{[1
,2
]}

Abrams, J. M. ^{[3
]}

Alnemri, E. S. ^{[4
]}

Baehrecke, E. H. ^{[5
]}

Blagosklonny, M. V. ^{[6
]}

Dawson, T. M. ^{[7
,8
]}

Dawson, V. L. ^{[7
,8
]}

El-Deiry, W. S. ^{[9
]}

Fulda, S. ^{[10
]}

Gottlieb, E. ^{[11
]}

Green, D. R. ^{[12
]}

Hengartner, M. O. ^{[13
]}

Kepp, O. ^{[1
,2
]}

Knight, R. A. ^{[14
]}

Kumar, S. ^{[15
,16
]}

Lipton, S. A. ^{[17
,18
,19
,20
]}

Lu, X. ^{[21
]}

Madeo, F. ^{[22
]}

Malorni, W. ^{[23
,24
]}

Mehlen, P. ^{[25
,26
,27
,28
]}

Nunez, G. ^{[29
]}

Peter, M. E. ^{[30
]}

Piacentini, M. ^{[31
,32
]}

Rubinsztein, D. C. ^{[33
]}

Shi, Y. ^{[34
]}

Simon, H-U ^{[35
]}

Vandenabeele, P. ^{[36
,37
]}

White, E. ^{[38
]}

Yuan, J. ^{[39
]}

Zhivotovsky, B. ^{[40
]}

Melino, G. ^{[41
,42
]}

Kroemer, G. ^{[1
,43
,44
,45
]}

机构：

[1] Inst Gustave Roussy, INSERM, Apoptosis Canc & Immun U848, F-94805 Villejuif, France

[2] Univ Paris 11, F-94805 Villejuif, France

[3] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

[4] Thomas Jefferson Univ, Dept Biochem & Mol Biol, Ctr Apoptosis Res, Kimmel Canc Inst, Philadelphia, PA 19107 USA

[5] Univ Massachusetts, Dept Canc Biol, Sch Med, Worcester, MA 01605 USA

[6] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

[7] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Neuroregenerat Program, Baltimore, MD 21205 USA

[8] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Stem Cell Program, Baltimore, MD 21205 USA

[9] Hershey Med Ctr, Canc Inst Penn State, Philadelphia, PA 17033 USA

[10] Goethe Univ, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

[11] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[12] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[13] Univ Zurich, Inst Mol Life Sci, CH-8057 Zurich, Switzerland

[14] UCL, Inst Child Hlth, London WC1N 3JH, England

[15] SA Pathol, Ctr Canc Biol, Adelaide, SA 5000, Australia

[16] Univ Adelaide, Dept Med, Adelaide, SA 5005, Australia

[17] Sanford Burnham Med Res Inst, San Diego, CA 92037 USA

[18] Salk Inst Biol Studies, La Jolla, CA 92037 USA

[19] Scripps Res Inst, La Jolla, CA 92037 USA

[20] Univ Calif San Diego, La Jolla, CA 92093 USA

[21] Ludwig Inst Canc Res, Oxford OX3 7DQ, England

[22] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

[23] Ist Super Sanita, Sect Cell Aging & Degenerat, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy

[24] Ist San Raffaele Sulmona, I-67039 Sulmona, Italy

[25] CRCL, F-69008 Lyon, France

[26] INSERM, U1052, F-69008 Lyon, France

[27] CNRS, UMR5286, F-69008 Lyon, France

[28] Ctr Leon Berard, F-69008 Lyon, France

[29] Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA

[30] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60637 USA

[31] Natl Inst Infect Dis IRCCS L Spallanzani, Cell Biol Lab, I-00149 Rome, Italy

[32] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

[33] Cambridge Inst Med Res, Cambridge CB2 0XY, England

[34] Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

[35] Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland

[36] Univ Ghent, Dept Mol Biol, B-9052 Ghent, Belgium

[37] VIB, Dept Mol Biomed Res, B-9052 Ghent, Belgium

[38] Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[39] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[40] Karolinska Inst, Inst Environm Med, Div Toxicol, S-17177 Stockholm, Sweden

[41] Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab IDI IRCCS, I-00133 Rome, Italy

[42] Univ Leicester, Toxicol Unit, Med Res Council, Leicester LE1 9HN, Leics, England

[43] Ctr Rech Cordeliers, F-75005 Paris, France

[44] Hop Europe Georges Pompidou, AP HP, F-75908 Paris, France

[45] Univ Paris 05, F-75270 Paris, France

来源：

CELL DEATH AND DIFFERENTIATION | 2012年 / 19卷 / 01期

基金：

美国国家科学基金会;

关键词：

autophagy; mitochondrial membrane permeabilization; necroptosis; parthanatos; TNFR1; TP53; APOPTOSIS-INDUCING FACTOR; MITOCHONDRIAL-MEMBRANE PERMEABILIZATION; NEUTROPHIL EXTRACELLULAR TRAPS; POLY(ADP-RIBOSE) PAR POLYMER; CASPASE-MEDIATED CLEAVAGE; STRESS-INDUCED APOPTOSIS; BREAST-CANCER CELLS; NECROSIS-FACTOR TNF; MITOTIC CATASTROPHE; CYTOCHROME-C;

D O I：

10.1038/cdd.2011.96

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including 'apoptosis', 'necrosis' and 'mitotic catastrophe'. In view of the substantial progress in the biochemical and genetic exploration of cell death, time has come to switch from morphological to molecular definitions of cell death modalities. Here we propose a functional classification of cell death subroutines that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic apoptosis, regulated necrosis, autophagic cell death and mitotic catastrophe. Moreover, we discuss the utility of expressions indicating additional cell death modalities. On the basis of the new, revised NCCD classification, cell death subroutines are defined by a series of precise, measurable biochemical features. Cell Death and Differentiation (2012) 19, 107-120; doi:10.1038/cdd.2011.96; published online 15 July 2011

引用

页码：107 / 120

页数：14

共 180 条

[1] The PARP superfamily [J].

Amé, JC ;

Spenlehauer, C ;

de Murcia, G .

BIOESSAYS, 2004, 26 (08) :882-893

[2] Poly(ADP-ribose) (PAR) polymer is a death signal [J].

Andrabi, Shaida A. ;

Kim, No Soo ;

Yu, Seong-Woon ;

Wang, Hongmin ;

Koh, David W. ;

Sasaki, Masayuki ;

Klaus, Judith A. ;

Otsuka, Takashi ;

Zhang, Zhizheng ;

Koehler, Raymond C. ;

Hurn, Patricia D. ;

Poirier, Guy G. ;

Dawson, Valina L. ;

Dawson, Ted M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (48) :18308-18313

[3] Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity [J].

Bano, D ;

Young, KW ;

Guerin, CJ ;

LeFeuvre, R ;

Rothwell, NJ ;

Naldini, L ;

Rizzuto, R ;

Carafoli, E ;

Nicotera, P .

CELL, 2005, 120 (02) :275-285

[4] The CD95 type I/type II model [J].

Barnhart, BC ;

Alappat, EC ;

Peter, ME .

SEMINARS IN IMMUNOLOGY, 2003, 15 (03) :185-193

[5] Pyroptosis: host cell death and inflammation [J].

Bergsbaken, Tessa ;

Fink, Susan L. ;

Cookson, Brad T. .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (02) :99-109

[6] CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4+ T cells [J].

Berndt, C ;

Möpps, B ;

Angermüller, S ;

Gierschik, P ;

Krammer, PH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12556-12561

[7] Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila [J].

Berry, Deborah L. ;

Baehrecke, Eric H. .

CELL, 2007, 131 (06) :1137-1148

[8] cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination [J].

Bertrand, Mathieu J. M. ;

Milutinovic, Snezana ;

Dickson, Kathleen M. ;

Ho, Wai Chi ;

Boudreault, Alain ;

Durkin, Jon ;

Gillard, John W. ;

Jaquith, James B. ;

Morris, Stephen J. ;

Barker, Philip A. .

MOLECULAR CELL, 2008, 30 (06) :689-700

[9] The death-associated protein kinases: Structure, function, and beyond [J].

Bialik, Shani ;

Kimchi, Adi .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :189-210

[10] Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain [J].

Bizat, N ;

Galas, MC ;

Jacquard, C ;

Boyer, F ;

Hermel, JM ;

Schiffmann, SN ;

Hantraye, P ;

Blum, D ;

Brouillet, E .

NEUROPHARMACOLOGY, 2005, 49 (05) :695-702

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