Pharmacogenetics of anti-HIV drugs

被引：54

作者：

Telenti, A. ^{[1
]}

Zanger, U. M. ^{[2
,3
]}

机构：

[1] Univ Lausanne, Inst Microbiol, CH-1011 Lausanne, Switzerland

[2] Univ Tubingen, D-72074 Tubingen, Germany

[3] Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2008年 / 48卷

关键词：

protease inhibitors; non-nucleoside reverse transcriptase inhibitors; nucleoside analogue reverse transcriptase inhibitors; HIV susceptibility; ADME proteins;

D O I：

10.1146/annurev.pharmtox.48.113006.094753

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacogenetics holds promise in HIV treatment because of the complexity and potential toxicity of multidrug therapies that are prescribed for long periods. Thus far, few candidate genes have been examined for a limited number of allelic variants, but a number of confirmed associations have already emerged. A change in paradigm emerges from the availability of the HapMap, the wealth of data on less-common genetic polymorphisms, and new genotyping technology. This review presents a comprehensive analysis of the existing literature on pharmacogenetic determinants of antiretroviral drug exposure, drug toxicity, as well as genetic markers associated with the rate of disease progression. It is expected that larger-scale comprehensive genome approaches will profoundly change the landscape of knowledge in the future.

引用

页码：227 / 256

页数：30

共 161 条

[1] Efavirenz [J].

Adkins, JC ;

Noble, S .

DRUGS, 1998, 56 (06) :1055-1064

[2] A single-nucleotide polymorphism tagging set for human drug metabolism and transport [J].

Ahmadi, KR ;

Weale, ME ;

Xue, ZYY ;

Soranzo, N ;

Yarnall, DP ;

Briley, JD ;

Maruyama, Y ;

Kobayashi, M ;

Wood, NW ;

Spurr, NK ;

Burns, DK ;

Roses, AD ;

Saunders, AM ;

Goldstein, DB .

NATURE GENETICS, 2005, 37 (01) :84-89

[3] Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors [J].

Akiyama, TE ;

Gonzalez, FJ .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2003, 1619 (03) :223-234

[4] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[5] Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study [J].

Anderson, Peter L. ;

Lamba, Jatinder ;

Aquilante, Christina L. ;

Schuetz, Erin ;

Fletcher, Courtney V. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 42 (04) :441-449

[6] The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities [J].

Anderson, PL ;

Kakuda, TN ;

Lichtenstein, KA .

CLINICAL INFECTIOUS DISEASES, 2004, 38 (05) :743-753

[7] Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy [J].

Arnedo, Mireia ;

Taffe, Patrick ;

Sahli, Roland ;

Furrer, Hansjakob ;

Hirschel, Bernard ;

Elzi, Luigia ;

Weber, Rainer ;

Vernazza, Pietro ;

Bernasconi, Enos ;

Darioli, Roger ;

Bergmann, Sven ;

Beckmann, Jacques S. ;

Telenti, Amalio ;

Tarr, Philip E. .

PHARMACOGENETICS AND GENOMICS, 2007, 17 (09) :755-764

[8] Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients [J].

Baede-van Dijk, PA ;

Hugen, PWH ;

Verweij-van Wissen, CPWGM ;

Koopmans, PP ;

Burger, DM ;

Hekster, YA .

AIDS, 2001, 15 (08) :991-998

[9]

Barrett JS, 2002, INT J CLIN PHARM TH, V40, P507

[10] Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1 [J].

Bashirova, Arman A. ;

Bleiber, Gabriela ;

Qi, Ying ;

Hutcheson, Holli ;

Yamashita, Traci ;

Johnson, Randall C. ;

Cheng, Jie ;

Alter, Galit ;

Goedert, James J. ;

Buchbinder, Susan ;

Hoots, Keith ;

Vlahov, David ;

May, Margaret ;

Maldarelli, Frank ;

Jacobson, Lisa ;

O'Brien, Stephen J. ;

Telenti, Amalio ;

Carrington, Mary .

JOURNAL OF VIROLOGY, 2006, 80 (14) :6757-6763

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