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The role of TALL-1 and APRIL in immune regulation

被引：27
作者：
Khare, SD
Hsu, HL
机构：
[1] Amgen Inc, Dept Pathol Pharmacol, Thousand Oaks, CA 91320 USA
[2] Amgen Inc, Dept Inflammat, Thousand Oaks, CA 91320 USA
来源：
TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 02期
关键词：
D O I：
10.1016/S1471-4906(00)01843-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Members of the tumor necrosis factor (TNF) superfamily play important roles in cell proliferation and death during immune regulation. Most members are synthesized as type II transmembrane proteins; the carboxy terminal extracellular domain can be cleaved from the cell membrane to form soluble active cytokines that bind to appropriate members of the TNF receptor family Here, we describe the biological significance of recently discovered members of the TNF superfamily (TALL-1 and APRIL) and their receptors (TACI and BCMA) in the pathophysiology of human diseases.
引用
收藏
页码：61 / 63
页数：3
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