Simple procedure for operating a class of continuous fermentation processes at the optimal steady state productivity

This paper attempts to develop a procedure for operating a class of continuous fermentation processes at the optimal steady state productivity. Based on a nonsegregated fermentation process model, we have found that an experimental procedure is feasible for identifying the unknown process parameters. Once those parameters have been identified, the optimal set points for feed substrate concentration, and dilution rate can be set up accordingly. Finally, we show that this simple procedure is robust against measurement inaccuracy. (C) 1998 Elsevier Science S.A.