Sequence of a pyrimidine-selective Na+/nucleoside cotransporter from pig kidney, pkCNT1

被引：9

作者：

Pajor, AM ^{[1
]}

机构：

[1] Univ Arizona, Coll Med, Dept Physiol, Tucson, AZ 85724 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1998年 / 1415卷 / 01期

关键词：

transport; sodium; nucleoside; uridine; kidney;

D O I：

10.1016/S0005-2736(98)00192-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 3 kb cDNA called pkCNT1, a new member of the Na+/nucleoside cotransporter family, was cloned from pig kidney and sequenced. The sequence of pkCNT1 encodes a 647 amino acid protein that is 84% identical to the sequence of the rat pyrimidine-selective Na+/nucleoside cotransporter, rCNT1. pkCNT1 transports pyrimidines, such as thymidine and uridine, and has a K-m for uridine of 9 mu M. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：266 / 269

页数：4

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