Anti-HIV bioactive stilbene dimers of Caragana rosea

被引：38

作者：

Yang, GX

Zhou, IT

Li, YZ

Hu, CQ ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China

[2] Duke Univ, Med Ctr, Ctr AIDS Res, Durham, NC 27706 USA

[3] Shanghai Inst Chinese Mat Med, Shanghai, Peoples R China

来源：

PLANTA MEDICA | 2005年 / 71卷 / 06期

关键词：

D O I：

10.1055/s-2005-864162

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the ethanol extract of the aerial parts of Caragana rosea Turcz. led to the isolation of two new (cararosinol C and cararosinol D) and four known [scirpLISin A (1), cis-scirpusin A (2), maackin (3), scirpusin B (4)] stilbene dimers. This is the first identification of these compounds from this plant and the first time that compound 2 has been isolated as a natural compound. Their structures were established mainly by spectral means. An in vitro assay against HIV-1([1]B), demonstrated compounds 1 and 4 to be active against HIV, with EC50 values of 10 mu g/mL and 7 mu g/mL respectively.

引用

页码：569 / 571

页数：3

共 11 条

[1] HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato [J].