Intracellular signalling: PDK1 - a kinase at the hub of things

被引：190

作者：

Belham, C ^{[1
]}

Wu, SL

Avruch, J

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Med Serv, Boston, MA 02114 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[4] Harvard Med Sch, Dept Med, Boston, MA 02114 USA

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(99)80058-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells.

引用

页码：R93 / R96

页数：4

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