Miniaturized QCM-based flow system for immunosensor application in liquid

被引：44

作者：

Michalzik, M ^{[1
]}

Wilke, R ^{[1
]}

Büttgenbach, S ^{[1
]}

机构：

[1] Tech Univ Braunschweig, Inst Microtechnol, D-3300 Braunschweig, Germany

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2005年 / 111卷

关键词：

thickness-shear-mode resonators; quartz crystal microbalance; PDMS; immunoassay;

D O I：

10.1016/j.snb.2005.03.048

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report on a poly(dimethylsiloxane) (PDMS) microfluidic analysis system based on mass sensitive detection. It consists of a miniaturized quartz crystal microbalance (QCM) and a flow cell made out of PDMS which is bonded to the quartz substrate. Protein A was used for the immobilization and the functionality of this undercoating was tested by accumulation of anti-protein A. The sensor system was operated in a flow-through mode and the results were compared with measurements using an injection method, where a definite amount of solution is injected into a reservoir mounted on the QCM. The conducted measurements proved the excellent performance of the new flow system. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：410 / 415

页数：6

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