Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin αvβ3-rich tumor cells

被引：362

作者：

Xie, Jin ^{[2
]}

Chen, Kai ^{[1
]}

Lee, Ha-Young ^{[1
]}

Xu, Chenjie ^{[2
]}

Hsu, Andrew R. ^{[1
]}

Peng, Sheng ^{[2
]}

Chen, Xiaoyuan ^{[1
]}

Sun, Shouheng ^{[2
]}

机构：

[1] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA

[2] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 24期

关键词：

D O I：

10.1021/ja802003h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a direct synthesis of ultrasmall c(RGDyK) peptide-coated Fe3O4 NPS (< 10 nm in hydrodynamic diameter) and demonstrate their in vivo tumor-specific targeting capability. The Fe3O4 NPs are synthesized by thermal decomposition fo iron pentacarbonyl in the presence of 4-methylcatechol (4-MC), and the peptide is coupled to nanoparticles through 4-MC via Mannich reaction. The c(RGDyK)-MC-Fe3O4 NPs have an overall diameter of similar to 8.4 nm and are stable in physiological conditions. When administered intravenously, these c(RGDyK)-MC-Fe3O4 NPs accumulate preferentially in the integrin alpha(v)beta(3)-rich tumor area, which are readily tracked by MRI.

引用

页码：7542 / +

页数：3

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