Role of extracellular vesicles in rheumatoid arthritis

被引：55

作者：

Fu, Haitao ^{[1
,2
]}

Hu, Die ^{[3
]}

Zhang, Licheng ^{[1
]}

Tang, Peifu ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army, Dept Orthoped, Gen Hosp, Beijing 100853, Peoples R China

[2] Nankai Univ, Sch Med, Tianjin 300110, Peoples R China

[3] Shandong Acad Med Sci, Qingdao Eye Hosp, Shandong Eye Inst, Qingdao 266071, Peoples R China

来源：

MOLECULAR IMMUNOLOGY | 2018年 / 93卷

关键词：

Extracellular vesicle; Rheumatoid arthritis; Signal communication; Pathogenesis; Inflammation; microRNA; FIBROBLAST-LIKE SYNOVIOCYTES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CELL-DERIVED MICROPARTICLES; COLLAGEN-INDUCED ARTHRITIS; REGULATORY T-CELLS; SYNOVIAL FIBROBLASTS; DENDRITIC CELLS; PLATELET MICROPARTICLES; TISSUE FACTOR; INFLAMMATORY DISEASES;

D O I：

10.1016/j.molimm.2017.11.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cell-derived extracellular vesicles (EVs) are involved in the pathogenesis of rheumatoid arthritis (RA), playing, important roles in antigen presentation, inflammation, angiogenesis, cell cell signal communication, thrombosis, and articular cartilage extracellular matrix degradation. Understanding the pathogenic mechanism of RA is important for developing therapies. The pathogenic indicators of RA, such as submicron-sized EVs, represent promising biomarkers for evaluating RA activity. This review summarizes the recent advances in understanding the pathogenesis of RA, and sheds light on the pathogenic as well as anti-inflammatory or immunosuppressive roles of EVs. We suggest that EVs could be harnessed as tools for drug delivery or targets for RA therapies.

引用

收藏

页码：125 / 132

页数：8

相关论文

共 117 条

[1]

Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis [J].

Abdollahi-Roodsaz, Shahla ;

Joosten, Leo A. B. ;

Roelofs, Mieke F. ;

Radstake, Timothy R. D. J. ;

Matera, Giovanni ;

Popa, Calin ;

van der Meer, Jos W. A. ;

Netea, Mihai G. ;

van den Berg, Wim B. .

ARTHRITIS AND RHEUMATISM, 2007, 56 (09) :2957-2967

[2]

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies [J].

Akers, Johnny C. ;

Gonda, David ;

Kim, Ryan ;

Carter, Bob S. ;

Chen, Clark C. .

JOURNAL OF NEURO-ONCOLOGY, 2013, 113 (01) :1-11

[3]

Alizadeh SH, 2014, IRAN J PEDIATR HEMAT, V4, P141

[4]

Bruton's Tyrosine Kinase Is Involved in miR-346-Related Regulation of IL-18 Release by Lipopolysaccharide-Activated Rheumatoid Fibroblast-Like Synoviocytes [J].

Alsaleh, Ghada ;

Suffert, Guillaume ;

Semaan, Noha ;

Juncker, Tom ;

Frenzel, Laurent ;

Gottenberg, Jacques-Eric ;

Sibilia, Jean ;

Pfeffer, Sebastien ;

Wachsmann, Dominique .

JOURNAL OF IMMUNOLOGY, 2009, 182 (08) :5088-5097

[5]

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models [J].

Arntz, Onno J. ;

Pieters, Bartijn C. H. ;

Oliveira, Marina C. ;

Broeren, Mathijs G. A. ;

Bennink, Miranda B. ;

de Vries, Marieke ;

van Lent, Peter L. E. M. ;

Koenders, Marije I. ;

van den Berg, Wim B. ;

van der Kraan, Peter M. ;

van de Loo, Fons A. J. .

MOLECULAR NUTRITION & FOOD RESEARCH, 2015, 59 (09) :1701-1712

[6]

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].

Arroyo, Jason D. ;

Chevillet, John R. ;

Kroh, Evan M. ;

Ruf, Ingrid K. ;

Pritchard, Colin C. ;

Gibson, Donald F. ;

Mitchell, Patrick S. ;

Bennett, Christopher F. ;

Pogosova-Agadjanyan, Era L. ;

Stirewalt, Derek L. ;

Tait, Jonathan F. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008

[7]

Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy [J].

Baglio, Serena Rubina ;

Pegtel, D. Michiel ;

Baldini, Nicola .

FRONTIERS IN PHYSIOLOGY, 2012, 3

[8]

Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles [J].

Barry, OP ;

Pratico, D ;

Lawson, JA ;

FitzGerald, GA .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (09) :2118-2127

[9]

Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism [J].

Berckmans, RJ ;

Nieuwland, R ;

Tak, PP ;

Böing, AN ;

Romijn, FPHTM ;

Kraan, MC ;

Breedveld, FC ;

Hack, CE ;

Sturk, A .

ARTHRITIS AND RHEUMATISM, 2002, 46 (11) :2857-2866

[10]

Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes [J].

Berckmans, RJ ;

Nieuwland, R ;

Kraan, MC ;

Schaap, MCL ;

Pots, D ;

Smeets, TJM ;

Sturk, A ;

Tak, PP .

ARTHRITIS RESEARCH & THERAPY, 2005, 7 (03) :R536-R544

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