Synthesis and characterization of poly(glycerol-succinic acid) dendrimers

被引:95
作者
Carnahan, MA
Grinstaff, MW [1 ]
机构
[1] Duke Univ, Paul M Gross Chem Lab, Dept Chem, Durham, NC 27708 USA
[2] Duke Univ, Paul M Gross Chem Lab, Dept Ophthalmol, Durham, NC 27708 USA
[3] Duke Univ, Med Ctr, Durham, NC 27708 USA
关键词
D O I
10.1021/ma010848n
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The syntheses of novel dendrimers composed of glycerol and succinic acid are described. These "biodendrimers" are composed entirely of building blocks known to be biocompatible or degradable in vivo to natural metabolites and are prepared using a high yield divergent approach. Moreover, the synthetic strategy employed is amenable to the design and development of new materials as demonstrated by the attachment of a photopolymerizable group.
引用
收藏
页码:7648 / 7655
页数:8
相关论文
共 88 条
[1]   Light-harvesting dendrimers [J].
Adronov, A ;
Fréchet, JMJ .
CHEMICAL COMMUNICATIONS, 2000, (18) :1701-1710
[2]  
Albrecht M, 2000, CHEM-EUR J, V6, P1431, DOI 10.1002/(SICI)1521-3765(20000417)6:8<1431::AID-CHEM1431>3.0.CO
[3]  
2-D
[4]  
[Anonymous], 1997, PRINCIPLES TISSUE EN
[5]   Designing dendrimers based on transition metal complexes. Light-harvesting properties and predetermined redox patterns [J].
Balzani, V ;
Campagna, S ;
Denti, G ;
Juris, A ;
Serroni, S ;
Venturi, M .
ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (01) :26-34
[6]   Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo [J].
Bielinska, AU ;
Yen, A ;
Wu, HL ;
Zahos, KM ;
Sun, R ;
Weiner, ND ;
Baker, JR ;
Roessler, BJ .
BIOMATERIALS, 2000, 21 (09) :877-887
[7]   About dendrimers: Structure, physical properties, and applications [J].
Bosman, AW ;
Janssen, HM ;
Meijer, EW .
CHEMICAL REVIEWS, 1999, 99 (07) :1665-1688
[8]   Hydroformylation reactions with rhodium-complexed dendrimers on silica [J].
Bourque, SC ;
Maltais, F ;
Xiao, WJ ;
Tardif, O ;
Alper, H ;
Arya, P ;
Manzer, LE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (13) :3035-3038
[9]  
BUHLEIER W, 1987, SYNTHESIS-STUTTGART, P155
[10]   Synthesis of benzylidene-protected dihydroxyacetone [J].
Carlsen, PHJ ;
Sorbye, K ;
Ulven, T ;
Aasbo, K .
ACTA CHEMICA SCANDINAVICA, 1996, 50 (02) :185-187