Column asymmetric catalysis for β-lactam synthesis

被引：86

作者：

Hafez, AM ^{[1
]}

Taggi, AE ^{[1
]}

Wack, H ^{[1
]}

Drury, WJ ^{[1
]}

Lectka, T ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol006659r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalytic asymmetric reaction process was designed involving the use of solid phase reagents and catalysts that constitute the packing of a series of "reaction columns". This process was applied to the catalytic asymmetric synthesis of beta -lactams, yielding pure product after crystallization with exceptional enantio- and diastereoselectivity.

引用

页码：3963 / 3965

页数：3

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