Mathematical modeling of magnesium oxide release from granules produced by laboratory fluidization

The particle size usually has an important effect on the rate of drug liberation from sustained release systems. The nature of that effect depends on the geometry of the system and the mechanism of the drug release (1). The aim of the present study was to characterize the relationship between the drug release profile of granules produced by laboratory fluidization and their particle size. The magnesium oxide release from granules-which are of two different particle sizes and contain Eudragit polymer-was investigated both experimentally and with mathematical models. First-order, cube root, square root, and two-thirds root models were applied for the evaluation of the drug release data. Changes in the particle size of the investigated granules altered the drug release profile.