Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine

被引：40

作者：

Cabedo, N

Protais, P

Cassels, BK

Cortes, D ^{[1
]}

机构：

[1] Univ Valencia, Fac Farm, Dept Farmacol Farmacognosia & Farmacodinamia, E-46100 Valencia, Spain

[2] Univ Rouen, Fac Med & Pharm, Physiol Lab, F-76800 St Etienne Rouvray, France

[3] Univ Chile, Fac Ciencias, Dept Quim, Santiago, Chile

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 06期

关键词：

D O I：

10.1021/np980008a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

(R)-(f)-nor-Roefractine (1) was synthesized by the Bischler-Napieralski route, using asymmetric reduction of the 1,2-didehydro precursor imine with sodium (S)-N-CBZ-prolinyloxyborohydride. Compound 1 was able to displace [H-3]-raclopride (a D-2 dopamine receptor-selective ligand) from its specific binding sites in rat striatum with selectivity vs [H-3]-SCH23390 (D-1 dopamine receptor-selective ligand).

引用

页码：709 / 712

页数：4

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