Threshold dose-response model-RIP: 1911 to 2006

This essay represents a serious but fictional obituary of a scientific concept called the Threshold Dose-Response Model, which has long dominated the fields of toxicology and the broader biomedical sciences. Recent evidence indicates that the Threshold Dose-Response Model has long outlived its utility to predict low-dose effects. In fact, so poorly does this model predict low-dose responses that the idea arose that it should receive a symbolic burial recounting its achievements and failings, hence this obituary.