Association study of neuregulin 1 gene with schizophrenia

被引：193

作者：

Yang, JZ

Si, TM

Ruan, Y

Ling, YS

Han, YH

Wang, XL

Zhou, M

Zhang, HY

Kong, QM

Liu, C

Zhang, DR

Yu, YQ

Liu, SZ

Ju, GZ

Shu, L

Ma, DL

Zhang, D ^{[1
]}

机构：

[1] Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

[2] Jilin Univ, Ctr Genom Med, Changchun 130021, Peoples R China

[3] Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

来源：

MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 07期

基金：

中国国家自然科学基金;

关键词：

schizophrenia; single nucleotide polymorphism (SNP); neuregulin 1(NRG1); the transmission disequilibrium test (TDT); haplotype;

D O I：

10.1038/sj.mp.4001377

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of studies have indicated that 8p22-p12 is likely to harbor schizophrenia susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may play a role in the pathogenesis of schizophrenia. Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. The transmission disequilibrium test analysis for each variant showed a significant difference between two transmitted alleles even after Bonferroni correction (rs3924999, P=0.007752; rs2954041, P=0.0009309; SNP8NRG221533, P=0.012606). The global chi(2) test for haplotype transmission also revealed a strong association (chi(2)=46.068, df=7, P<0.000001). Our results suggest that the NRG1 gene may play a role in conferring susceptibility to the disease.

引用

页码：706 / 709

页数：4

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