Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway

被引：50

作者：

Bai, Zhigang ^{[1
]}

Zhang, Zhongtao ^{[1
]}

Ye, Yingjiang ^{[2
]}

Wang, Shan ^{[2
]}

机构：

[1] Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China

[2] Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2010年 / 34卷 / 12期

关键词：

differentiation; gastric cancer; MUC2; PTEN; PI3K; sodium butyrate; PHOSPHATIDYLINOSITOL; 3-KINASE; HISTONE DEACETYLASE; GENE-EXPRESSION; PTEN; INHIBITION; PROTEINS;

D O I：

10.1042/CBI20090481

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

NaB (sodium butyrate) inhibits cell proliferation and induces differentiation in a variety of tumour cells. In this study, we aimed to determine whether NaB induced differentiation and regulated the expression of the mucosal factor MUC2 through the PTEN/PI3K (phosphoinositide 3-kinase) pathway. BGC823 cells treated with NaB for 24-72 h showed marked inhibition of cell proliferation and alteration in cellular morphology. NaB treatment markedly increased the expression of PTEN and MUC2, but it decreased the expression of PI3K. These effects were enhanced by intervention with PI3K inhibitors and were reduced by intervention with PTEN siRNA. Hence, we conclude that NaB increased PTEN expression, promoted the expression of MUC2 and induced the differentiation of gastric cancer cells through the PTEN/PI3K signalling pathway.

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收藏

页码：1141 / 1145

页数：5

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