Genetic code origins: tRNAs older than their synthetases?

被引：51

作者：

de Pouplana, LR ^{[1
]}

Turner, RJ ^{[1
]}

Steer, BA ^{[1
]}

Schimmel, P ^{[1
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 19期

关键词：

D O I：

10.1073/pnas.95.19.11295

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present a phylogenetic analysis to determine whether a given tRNA molecule was established in evolution before its cognate aminoacyl-tRNA synthetase. The earlier appearance of tRNA versus their metabolically related enzymes is a prediction of the RNA world theory, but the available synthetase and tRNA sequences previously had not allowed a formal comparison of their relative time of appearance. Using data recently obtained from the emerging genome projects, our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the establishment of the identity of lysine tRNA.

引用

页码：11295 / 11300

页数：6

共 29 条

[1] CATALYSIS BY THE RNA SUBUNIT OF RNASE-P - A MINIREVIEW [J].

ALTMAN, S ;

BAER, MF ;

BARTKIEWICZ, M ;

GOLD, H ;

GUERRIERTAKADA, C ;

KIRSEBOM, LA ;

LUMELSKY, N ;

PECK, K .

GENE, 1989, 82 (01) :63-64

[2]

[Anonymous], 1967, GENETIC CODE

[3] GENBANK [J].

BENSON, DA ;

BOGUSKI, M ;

LIPMAN, DJ ;

OSTELL, J .

NUCLEIC ACIDS RESEARCH, 1994, 22 (17) :3441-3444

[4] ROOT OF THE UNIVERSAL TREE OF LIFE BASED ON ANCIENT AMINOACYL-TRANSFER-RNA SYNTHETASE GENE DUPLICATIONS [J].

BROWN, JR ;

DOOLITTLE, WF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2441-2445

[5]

BULT CJ, 1996, SCIENCE, V273, P1017

[6]

CECH TR, 1986, ANNU REV BIOCHEM, V55, P599, DOI 10.1146/annurev.bi.55.070186.003123

[7] Aminoacyl-tRNA synthetases [J].

Cusack, S .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (06) :881-889

[8]

DEDAVE C, 1991, BLUEPRINT CELL NATUR

[9] Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria [J].

dePouplana, LR ;

Frugier, M ;

Quinn, CL ;

Schimmel, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :166-170

[10] EVOLUTION ACCORDING TO LARGE RIBOSOMAL-SUBUNIT RNA [J].

DERIJK, P ;

VANDEPEER, Y ;

VANDENBROECK, I ;

DEWACHTER, R .

JOURNAL OF MOLECULAR EVOLUTION, 1995, 41 (03) :366-375

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