Triple helix stabilization properties of oligonucleotides containing 8-amino-2′-deoxyguanosine

被引：11

作者：

García, RG

Bachi, A

Eritja, R

Luque, FJ

Orozco, M

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] Univ Barcelona, E-08028 Barcelona, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(98)00537-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analysis of the Hoogsteen base pairs of guanine and 8-aminoguanine with cytosine in the gase phase shows a strong stabilization of the 8-aminoguanine cytosine base pair due to the formation of an extra H-bond. Melting profiles of oligonucleotides carrying 8-amino-2'-deoxyguanosine confirm the triple helix stabilization properties of 8-aminoguanine. (C) 1998 Elsevier Science Ltd. Ail rights reserved.

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页码：3011 / 3016

页数：6

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