A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

被引：483

作者：

Pang, Roberta ^{[1
,2
]}

Law, Wai Lun ^{[3
]}

Chu, Andrew C. Y. ^{[2
]}

Poon, Jensen T. ^{[3
]}

Lam, Cohn S. C. ^{[1
]}

Chow, Ariel K. M. ^{[2
]}

Ng, Lui ^{[1
]}

Cheung, Leonard W. H. ^{[1
]}

Lan, Xiao R. ^{[1
]}

Lan, Hui Y. ^{[1
]}

Tan, Victoria P. Y. ^{[1
]}

Yau, Thomas C. ^{[1
]}

Poon, Ronnie T. ^{[2
,3
]}

Wong, Benjamin C. Y. ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Pokfulam, Hong Kong, Peoples R China

[2] Univ Hong Kong, Li Ka Shing Fac Med, Ctr Canc Res, Pokfulam, Hong Kong, Peoples R China

[3] Univ Hong Kong, Li Ka Shing Fac Med, Dept Surg, Pokfulam, Hong Kong, Peoples R China

来源：

CELL STEM CELL | 2010年 / 6卷 / 06期

关键词：

DIPEPTIDYL-PEPTIDASE-IV; HUMAN PANCREATIC-CANCER; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; EXTRACELLULAR-MATRIX; INITIATING CELLS; CARCINOMA CELLS; TUMOR-GROWTH; E-CADHERIN; IDENTIFICATION;

D O I：

10.1016/j.stem.2010.04.001

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26(+) cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26(+) cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26(+) cells, but not CD26(-) cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26(+) cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy.

引用

页码：603 / 615

页数：13

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