Cytokine concentrations in sputum of asthmatic patients

被引:86
作者
Konno, S [1 ]
Gonokami, Y [1 ]
Kurokawa, M [1 ]
Kawazu, K [1 ]
Asano, K [1 ]
Okamoto, K [1 ]
Adachi, M [1 ]
机构
[1] SHOWA UNIV,SCH MED,DEPT MED BIOL,TOKYO 142,JAPAN
关键词
cytokine; sputum; bronchial asthma;
D O I
10.1159/000237234
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
To examine whether levels of inflammatory cytokines and eosinophil cationic protein (ECP) in the sputum reflect the severity of bronchial asthma, we measured their levels in the sputum of symptomatic and asymptomatic asthmatics. Interleukin (IL)-1 beta, IL-5, IL-6, IL-8, RANTES, tumor necrosis factor-alpha and ECP concentrations in the sputum of symptomatic patients were significantly higher than in asymptomatic subjects. These findings suggest that these inflammatory cytokines are involved in the exacerbation of asthma.
引用
收藏
页码:73 / 78
页数:6
相关论文
共 24 条
[1]  
BARNES PJ, 1994, EUR RESPIR J, V7, P57
[2]   INTERLEUKIN-4, INTERLEUKIN-5, AND INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA IN NORMAL AND ASTHMATIC AIRWAYS - EVIDENCE FOR THE HUMAN MAST-CELL AS A SOURCE OF THESE CYTOKINES [J].
BRADDING, P ;
ROBERTS, JA ;
BRITTEN, KM ;
MONTEFORT, S ;
DJUKANOVIC, R ;
MUELLER, R ;
HEUSSER, CH ;
HOWARTH, PH ;
HOLGATE, ST .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1994, 10 (05) :471-480
[3]   CYTOKINES IN SYMPTOMATIC ASTHMA AIRWAYS [J].
BROIDE, DH ;
LOTZ, M ;
CUOMO, AJ ;
COBURN, DA ;
FEDERMAN, EC ;
WASSERMAN, SI .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (05) :958-967
[4]  
DOI S, 1994, CLIN EXP ALLERGY, V24, P854, DOI 10.1111/j.1365-2222.1994.tb01808.x
[5]   INTERLEUKIN-5 SYNTHESIS BY EOSINOPHILS - ASSOCIATION WITH GRANULES AND IMMUNOGLOBULIN-DEPENDENT SECRETION [J].
DUBUCQUOI, S ;
DESREUMAUX, P ;
JANIN, A ;
KLEIN, O ;
GOLDMAN, M ;
TAVERNIER, J ;
CAPRON, M ;
CAPRON, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) :703-708
[6]  
DUSTIN ML, 1986, J IMMUNOL, V137, P245
[7]  
EBISAWA M, 1994, J IMMUNOL, V152, P4590
[8]  
EBISAWA M, 1994, J IMMUNOL, V153, P2153
[9]  
ELSE KJ, 1991, IMMUNOLOGY, V72, P508
[10]  
FINOTTO S, 1994, J IMMUNOL, V153, P2278