Cytokine concentrations in sputum of asthmatic patients

被引：86

作者：

Konno, S ^{[1
]}

Gonokami, Y ^{[1
]}

Kurokawa, M ^{[1
]}

Kawazu, K ^{[1
]}

Asano, K ^{[1
]}

Okamoto, K ^{[1
]}

Adachi, M ^{[1
]}

机构：

[1] SHOWA UNIV,SCH MED,DEPT MED BIOL,TOKYO 142,JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1996年 / 109卷 / 01期

关键词：

cytokine; sputum; bronchial asthma;

D O I：

10.1159/000237234

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

To examine whether levels of inflammatory cytokines and eosinophil cationic protein (ECP) in the sputum reflect the severity of bronchial asthma, we measured their levels in the sputum of symptomatic and asymptomatic asthmatics. Interleukin (IL)-1 beta, IL-5, IL-6, IL-8, RANTES, tumor necrosis factor-alpha and ECP concentrations in the sputum of symptomatic patients were significantly higher than in asymptomatic subjects. These findings suggest that these inflammatory cytokines are involved in the exacerbation of asthma.

引用

页码：73 / 78

页数：6

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