Brain-derived neurotrophic factor: Linking fear learning to memory consolidation

被引：36

作者：

Monfils, Marie-H. ^{[1
]}

Cowansage, Kiriana K. ^{[1
]}

LeDoux, Joseph E. ^{[1
]}

机构：

[1] NYU, Ctr Neural Sci, New York, NY 10003 USA

来源：

MOLECULAR PHARMACOLOGY | 2007年 / 72卷 / 02期

关键词：

D O I：

10.1124/mol.107.038232

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays an important role in synaptic plasticity. In this issue of Molecular Pharmacology, Ou and Gean (p. 350) thoroughly describe the molecular cascade by which fear learning leads to an increase in BDNF expression in the lateral amygdala (LA). Calcium influx through N-methyl-D-aspartate receptors and L-type voltage-dependent calcium channels, which occurs in the LA during fear conditioning, activates protein kinase A and Ca2+/calmodulin-dependent protein kinase IV. Each induces phosphorylation of cAMP response element-binding protein, which binds to the BDNF promoter, leading to BDNF expression in the LA, and contributes to fear memory consolidation.

引用

页码：235 / 237

页数：3

共 39 条

[1] ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons [J].