0D/1D Heterojunction Implant with Electro-Mechanobiological Coupling Cues Promotes Osteogenesis

被引：44

作者：

Huang, Xiao ^{[1
]}

Xing, Jun ^{[1
]}

Wang, Zhengao ^{[1
]}

Han, Jin ^{[2
]}

Wang, Renxian ^{[3
]}

Li, Changhao ^{[1
]}

Xiao, Cairong ^{[1
]}

Lu, Fang ^{[4
]}

Zhai, Jinxia ^{[1
]}

Zhou, Zhengnan ^{[1
]}

Li, Yangfan ^{[1
]}

Zhou, Lei ^{[1
]}

Song, Zhiguo ^{[2
]}

Chen, Dafu ^{[3
]}

Yu, Peng ^{[1
]}

Ning, Chengyun ^{[1
]}

Jiang, Xieyuan ^{[3
]}

机构：

[1] South China Univ Technol, Sch Mat Sci & Engn, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Metall Mat Surface Functionalizat Engn Res Ctr Gu, Guangzhou 510641, Peoples R China

[2] Kunming Univ Sci & Technol, Sch Mat Sci & Engn, Kunming 650093, Yunnan, Peoples R China

[3] Beijing Jishuitan Hosp, Lab Bone Tissue Engn, Beijing Lab Biomed Mat, Beijing Res Inst Orthopaed & Traumatol, Beijing 100035, Peoples R China

[4] Beijing Univ Chinese Med, Sch Preclin Med, Beijing 100029, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2021年 / 31卷 / 50期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

bismuth oxide nanodots; electro-mechanobiology; heterojunction; osteogenesis; titanium dioxide nanocones; PHASE-TRANSITION; DIFFERENTIATION; PHOTOCATALYST; BIOMATERIALS; REGENERATION; BI2O3/TIO2; NANOTUBES; STRATEGY;

D O I：

10.1002/adfm.202106249

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Mimicking the natural bone extracellular matrix containing intrinsic topography and electrical signals is an effective way to modulate bone regeneration. However, simultaneously coupling of the intrinsic mechanobiology and electrical cues of implant to modulate bone regeneration remains ignored. Here, the authors report in situ designation of titanium dioxide (TiO2) nanocone/bismuth oxide (Bi2O3) nanodot heterojunctions on bone implant surface to electro-biomechanically trigger osseointegration at bone/implant interface. TiO2 nanocone/Bi2O3 nanodot heterojunctions exhibit built-in electric field at the nanoscale interface and elastic modulus equivalent to that of bone tissue. The nano-heterojunctions significantly promoted the attachment, spreading, and osteogenic differentiation of bone marrow mesenchymal stem cells in vitro, and the osteogenesis in vivo. The authors also show that the effects of nano-heterojunctions on osteogenesis are mediated by yes-associated protein biomechanical signal pathway and intracellular enrichment induced Phosphatidylinositol 3-kinase signal pathway. Their findings highlight the coupling of topographical and electric parameters of biomaterials for modulating cell behaviors.

引用

页数：10

共 49 条

[1]

Possible involvement of PI3K/AKT/mTOR signaling pathway in the protective effect of selegiline (deprenyl) against memory impairment following ischemia reperfusion in rat [J].