Molecular mechanisms of erythropoietin signaling

被引：46

作者：

Cheung, JY

Miller, BA

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Div Nephrol,Dept Med, Hershey, PA 17033 USA

[2] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

[3] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Pediat, Hershey, PA 17033 USA

来源：

NEPHRON | 2001年 / 87卷 / 03期

关键词：

erythropoietin; hematopoiesis; second messengers; JAK2; intracellular calcium; cytokine receptors;

D O I：

10.1159/000045918

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Erythropoietin is an obligatory growth factor for red blood cell production. The receptor for erythropoietin contains a single membrane-spanning domain with no intrinsic tyrosine kinase motifs. On binding to erythropoietin, the receptor dimerizes and activates multiple intracellular signaling molecules, including but not limited to JAK2, STAT5, PI 3-kinase, IRS-2, RAS, and Ca2+ channels. This review focuses on cytoplasmic signaling cascades involved in erythropoietin action. Copyright (C) 2002 S. Karger AG, Basel.

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收藏

页码：215 / 222

页数：8

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