A membrane metabolon linking carbonic anhydrase with chloride/bicarbonate anion exchangers

被引:87
作者
Reithmeier, RAF [1 ]
机构
[1] Univ Toronto, Dept Med, CIHR Grp Membrane Biol, Dept Med, Toronto, ON M5S 1A8, Canada
关键词
D O I
10.1006/bcmd.2000.0353
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The erythrocyte Cl-/HCO3-, anion exchanger (AE1, Band 3) and the enzyme carbonic anhydrase (CA) catalyze interconnected processes involved in bicarbonate metabolism. The high activity form of carbonic anhydrase, CAII binds to an acidic motif located within the carboxyl-terminal tail of anion exchangers via its basic amino-terminal region. CAII is thereby positioned at the cytosolic surface of the membrane, ideally placed to catalyze CO2 hydration and to channel bicarbonate to or from the anion exchanger. This association of a soluble enzyme and a membrane transporter may be an example of a metabolon, a weakly associated complex of sequential metabolic enzymes. (C) 2001 Academic Press.
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页码:85 / 89
页数:5
相关论文
共 26 条
[1]   Effect of PCMBS on CO2 permeability of Xenopus oocytes expressing aquaporin 1 or its C189S mutant [J].
Cooper, GJ ;
Boron, WF .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1998, 275 (06) :C1481-C1486
[2]   ROLE OF CARBONIC-ANHYDRASE INHIBITORS ON ANION PERMEABILITY INTO OX-RED-BLOOD-CELLS [J].
COUSIN, JL ;
MOTAIS, R .
JOURNAL OF PHYSIOLOGY-LONDON, 1976, 256 (01) :61-80
[3]   CARBONIC-ANHYDRASE ACTIVITY OF INTACT CARBONIC ANHYDRASE-II-DEFICIENT HUMAN-ERYTHROCYTES [J].
DODGSON, SJ ;
FORSTER, RE ;
SLY, WS ;
TASHIAN, RE .
JOURNAL OF APPLIED PHYSIOLOGY, 1988, 65 (04) :1472-1480
[4]  
GUTKNECHT J, 1977, J GEN PHYSIOL, V69, P779
[5]  
Hoffman J F, 1997, Curr Opin Hematol, V4, P112
[6]   CRYSTAL-STRUCTURE OF HUMAN ERYTHROCYTE CARBONIC-ANHYDRASE B - 3-DIMENSIONAL STRUCTURE AT A NOMINAL 2.2-A RESOLUTION .2. [J].
KANNAN, KK ;
NOTSTRAND, B ;
FRIDBORG, K ;
LOVGREN, S ;
OHLSSON, A ;
PETEF, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (01) :51-55
[7]   ERYTHROCYTE CARBONIC ANHYDRASE-I - INHERITED DEFICIENCY IN HUMANS [J].
KENDALL, AG ;
TASHIAN, RE .
SCIENCE, 1977, 197 (4302) :471-472
[8]  
KIFOR G, 1993, J MEMBRANE BIOL, V134, P169
[9]   CRYSTAL-STRUCTURE OF HUMAN CARBONIC ANHYDRASE-C [J].
LILJAS, A ;
LOVGREN, S ;
BERGSTEN, PC ;
CARLBOM, U ;
PETEF, M ;
WAARA, I ;
STRANDBERG, B ;
FRIDBORG, K ;
JARUP, L ;
KANNAN, KK .
NATURE-NEW BIOLOGY, 1972, 235 (57) :131-+
[10]   MEMBRANE-BOUND ATP FUELS THE NA-K PUMP - STUDIES ON MEMBRANE-BOUND GLYCOLYTIC-ENZYMES ON INSIDE-OUT VESICLES FROM HUMAN RED-CELL MEMBRANES [J].
MERCER, RW ;
DUNHAM, PB .
JOURNAL OF GENERAL PHYSIOLOGY, 1981, 78 (05) :547-568