Synthesis of (-)-agelastatin a by [3.3] sigmatropic rearrangement of allyl cyanate

被引：70

作者：

Ichikawa, Yoshiyasu ^{[1
]}

Yamaoka, Tomonori ^{[1
]}

Nakano, Keiji ^{[1
]}

Kotsuki, Hiyoshizo ^{[1
]}

机构：

[1] Kochi Univ, Fac Sci, Kochi 7808520, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 16期

关键词：

D O I：

10.1021/ol0709735

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of (-)-agelastatin A has been achieved starting from L-arabitol. The highlights in our synthesis include the preparation of vicinal diamine moiety by [3.3] sigmatropic rearrangement of allyl cyanate and construction of central ring-C with ring-closing metathesis.

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页码：2989 / 2992

页数：4

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